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KMID : 0388019930040040081
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Korean Journal Gynecologic Oncology and Colposcopy
1993 Volume.4 No. 4 p.81 ~ p.89
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Light Microscopic Study of the Ovary in Patients Receiving Chemotherapy
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최은주
차순도/박윤정/남동호/이은우/이태성/이탁/박관규
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Abstract
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To examine the cytotoxic effect of chemotherapy on the ovary, 23 cases undergoing oophorectomy with radical hysterectomy in premenopausal women receiving induction chemotherapy with cisplatin and 5―fluorouracil for carcinoma of the cervix
between
March, 1989 and December, 1992 were studied by light microscopy.
Out of 23 cases, 19 (82.6%) showed vascular congestion and 12(52.1%) revealed hemorrhage around follicle and within corpus luteum.
The follicular structure was destroyed in 16 cases (69.5%) and oocytes of ovums were lost in 17 cases.
The mechanism of injury of the ovarian structures after combination chemotherapy with cisplatin and 5―fluorouracil is considered to be caused by secondary cell damage following circulatory disturbance of direct toxicity on follicular cells of
oocytes.
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KEYWORD
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